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Thursday, April 25, 2013

Lipitor

consult your Doctor before taking any prescription drugs. For more info on these prescription drugs and side effects, visit: www.webmd.com










LIPITOR is a synthetic lipid-lowering agent. Atorvastatin is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. This enzyme catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis.

 

Atorvastatin calcium is a white to off-white crystalline powder that is insoluble in aqueous solutions of pH 4 and below. Atorvastatin calcium is very slightly soluble in distilled water, pH 7.4 phosphate buffer, and acetonitrile; slightly soluble in ethanol; and freely soluble in methanol.

LIPITOR Tablets for oral administration contain 10, 20, 40, or 80 mg atorvastatin and the following inactive ingredients: calcium carbonate, USP; candelilla wax, FCC; croscarmellose sodium, NF; hydroxypropyl cellulose, NF; lactose monohydrate, NF; magnesium stearate, NF; microcrystalline cellulose, NF; Opadry White YS-1-7040 (hypromellose, polyethylene glycol, talc, titanium dioxide); polysorbate 80, NF; simethicone emulsion.

 

 

Possible side effects of Lipitor:

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking atorvastatin and call your doctor at once if you have any of these serious side effects:

·        unexplained muscle pain, tenderness, or weakness;

·        fever, unusual tiredness, and dark colored urine;

·        swelling, weight gain, urinating less than usual or not at all; or

·        nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin)

 

 

 
What are the precautions when taking Lipitor?

Before taking atorvastatin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, alcohol use.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Limit alcoholic beverages. Daily use of alcohol may increase your risk for liver problems, especially when combined with atorvastatin.

 

What other drugs will affect Lipitor?

Many drugs can interact with Lipitor. Below is just a partial list. Tell your doctor if you are using:
  • birth control pills;
  • cimetidine (Tagamet);
  • conivaptan (Vaprisol);
  • imatinib (Gleevec);
  • isoniazid (for treating tuberculosis);
  • spironolactone (Aldactone, Aldactazide);
  • an antibiotic such as dalfopristin/quinupristin (Synercid), rifampin (Rifater, Rifadin, Rifamate), telithromycin (Ketek), and others;
  • an antidepressant such as nefazodone;
  • heart or blood pressure medication such as digoxin (Lanoxin), diltiazem (Cartia, Cardizem), nicardipine (Cardene), quinidine (Quin-G), verapamil (Calan, Covera, Isoptin, Verelan), and others;
  • HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva, Atripla), indinavir (Crixivan), and others; or
  • any other "statin" medication such as amlodipine and atorvastatin (Caduet), fluvastatin (Lescol), lovastatin (Altoprev, Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zocor, Simcor, Vytorin).
This list is not complete and there are many other drugs that can increase your risk of serious medical problems if you take them together with Lipitor. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.


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What should I avoid while taking Lipitor?

Avoid eating foods that are high in fat or cholesterol. Lipitor will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.
Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.
Grapefruit and grapefruit juice may interact with Lipitor and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
 
 
 

 
 
 





 
 
 
 
 










 
 
 

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How should I take Lipitor?

Take Lipitor exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Do not break an Lipitor tablet unless your doctor has told you.
Lipitor is usually taken once a day, with or without food. Take the medicine at the same time each day. Your doctor may occasionally change your dose to make sure you get the best results.
You may need to stop using Lipitor for a short time if you have:
  • uncontrolled seizures;
  • an electrolyte imbalance (such as high or low potassium levels in your blood);
  • severely low blood pressure;
  • a severe infection or illness; or surgery.
To be sure Lipitor is helping your condition and is not causing harmful effects, your blood will need to be tested often. Visit your doctor regularly.
 
 
 
 

 
 
 
 
 
 
 
 

 
 
 
 

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Lipitor es un agente reductor de lípidos sintéticos. La atorvastatina es un inhibidor de la 3-hidroxi-3-metilglutaril-coenzima A reductasa (HMG-CoA). Esta enzima cataliza la conversión de HMG-CoA a mevalonato, un paso temprano y limitante de la velocidad en la biosíntesis del colesterol.
La atorvastatina cálcica es de color blanco a blanquecino polvo cristalino que es insoluble en soluciones acuosas de pH 4 y por debajo. La atorvastatina calcio es muy ligeramente soluble en agua destilada, pH 7,4 tampón de fosfato, y acetonitrilo, ligeramente soluble en etanol y libremente soluble en metanol.Tabletas LIPITOR para la administración oral contienen 10, 20, 40, o 80 mg de atorvastatina y los siguientes ingredientes inactivos: carbonato de calcio, USP; cera de candelilla, FCC; croscarmelosa sódica, NF; hidroxipropil celulosa, NF; lactosa monohidrato, NF; estearato de magnesio, NF; celulosa microcristalina, NF; Opadry White YS-1-7040 (hipromelosa, polietilenglicol, talco, dióxido de titanio); polisorbato 80, NF; emulsión de simeticona.

Posibles efectos secundarios de Lipitor:Busque atención médica de emergencia si usted tiene alguno de estos síntomas de una reacción alérgica: ronchas, dificultad para respirar, hinchazón de la cara, labios, lengua, o garganta.Deje de tomar atorvastatina y llame a su médico de inmediato si usted tiene alguno de estos efectos secundarios graves:• dolor muscular inexplicable, sensibilidad, o debilidad;• fiebre, cansancio inusual, y orina oscura;• hinchazón, ganancia de peso, orinar menos de lo usual o nada en absoluto, o• náusea, dolor de estómago superior, picazón, pérdida del apetito, orina oscura, heces de color arcilla, ictericia (color amarillo de la piel)


¿Cuáles son las precauciones a la hora de tomar Lipitor?Antes de tomar atorvastatin, dígale a su médico o farmacéutico si usted es alérgico a éste, o si padece de cualquier otra alergia. Este producto puede contener ingredientes inactivos que pueden causar reacciones alérgicas u otros problemas. Hable con su farmacéutico para obtener más detalles.Antes de usar este medicamento, informe a su médico o farmacéutico acerca de su historial médico, especialmente acerca de: enfermedad hepática, enfermedad renal, consumo de alcohol.Antes de someterse a una cirugía, informe a su médico o dentista de todos los productos que usa (incluidos los medicamentos con o sin receta y los productos herbales).Limite las bebidas alcohólicas. El uso diario de alcohol puede aumentar su riesgo de problemas hepáticos, especialmente cuando se combina con atorvastatina.